KEY ROLE OF PIRNAS IN TELOMERIC CHROMATIN MAINTENANCE AND TELOMERE NUCLEAR POSITIONING IN DROSOPHILA GERMLINE

Key role of piRNAs in telomeric chromatin maintenance and telomere nuclear positioning in Drosophila germline

Abstract Background Telomeric small RNAs related to PIWI-interacting RNAs (piRNAs) have been described in various eukaryotes; however, their role in germline-specific telomere function remains poorly understood.Using a Drosophila model, we performed an in-depth study of the biogenesis of telomeric piRNAs and their function in telomere homeostasis i

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Madecassoside encapsulated in alginate chitosan nanoparticles exerts anti-excitotoxicity effects in pilocarpine-induced seizure

Madecassoside (MAD), a pentacyclic triterpenoid saponin, and its source herb Centella asiatica are best known for their memory enhancing and neuroprotective properties.The effects of MAD- and similar secondary metabolite-encapsulated nanoparticles on brain are least explored.Henceforth, we have developed MAD encapsulated alginate chitosan nanoparti

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Two pedigrees with restless legs syndrome in Brazil

Numerous studies have suggested a substantial genetic contribution in the etiology of the primary form of restless legs syndrome (RLS) and periodic leg movements (PLM).We describe the symptoms, the sleep profiles and physiological parameters Coupe Glasses of two families in which several members present RLS/PLM.The proband of family 1 is a 70-year-

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